Latest Study Result Reports
Barbara A.Goldstein, Martin L.Lenhardt, and Abraham Shulman.
Reprinted from the International Tinnitus Journal.
Published UltraQuiet related articles
The following are abstracts of published articles related to the UltraQuiet device, click on the title of the article to read the entire article in PDF form.
Barbara A.Goldstein,1 Martin L.Lenhardt,2 and Abraham Shulman1
1Department of Otolaryngology, State University of New York, Downstate Medical Center, Brooklyn,and Martha Entenmann Tinnitus Research Center, Forest Hills, New York,and 2 Program in Biomedical Engineering,Virginia Commonwealth University,Richmond,Virginia.
This study reports on the long-term benefit of ultra-high-frequency masking with the UltraQuiet device.A commercial product,UltraQuiet provides a new form of high-frequency bone conduction therapy.To assess its effectiveness in tinnitus treatment, we selected 15 patients with problematic tinnitus and randomly assigned them to three variations of the medical-audiological tinnitus patient protocol modified for the UltraQuiet study.We assessed tinnitus relief by questionnaires directed at weighing patient esponse to overall effectiveness, tinnitus loudness, tinnitus severity,and tinnitus annoyance. Additionally,we performed audiological measures (including pure-tone and speech audiometry,minimal masking levels,pitch and loudness matching,and residual inhibition).All patients showed some long-term gains,and most exhibited relief in at least one measurement parameter, providing support for the use of high-frequency vibration in the treatment of tinnitus.
high-frequency bone conduction;minimal masking levels; positron emission tomography; tinnitus questionnaires; ultra-high frequency.
International Tinnitus Journal,Vol.11,No.1,14 22 (2005)
Abraham Shulman,1,5 Arnold M.Strashun,2 Matthew J.Avitable,3 Martin L.Lenhardt,4 and Barbara A.Goldstein 1,5
1 Departments of Otolaryngology Head and Neck Surgery and 2 Nuclear Medicine,King s County Hospital, and 3 Scientific Computing Center at Downstate Medical Center State University of New York,Brooklyn,New York; 4 Virginia Commonwealth University,Richmond,Virginia;and 5 Martha Entenmann Tinnitus Research Center,Inc.,Forest Hills,New York.
Abstract:Ultra-high-frequency (UHF)external acoustic stimulation with the UltraQuiet device (UQ) has been reported to provide significant relief of severe disabling-type tinnitus.The nuclear medicine imaging technique of positron emission tomography (PET)was selected as a monitoring system to compare objectively metabolic alterations in brain function before and after UHF/UQ and to correlate the PET data with the subjective behavioral response of patients reporting tinnitus relief. PET of brain was completed on 6 patients randomly selected from a cohort of 15 patients included in a protocol to establish long-term tinnitus relief with UHF/UQ. Twelve specific regions of interest (ROI)were selected for PET of brain examination on the basis of results obtained with single-photon emission computed tomography (SPECT) of brain examinations recommended for patients with severe disabling-type tinnitus and demonstrating significant perfusion asymmetries in the right and left brain ROI of the primary auditory cortex;frontal,temporal,parietal,and medial temporal lobes;and cerebellum.
minimal masking levels; positron emission tomography; single-photon emission tomography; tinnitology; ultra-high-frequency
International Tinnitus Journal, Vol.10, No.2, 113 125 (2004)
Barbara A. Goldstein(a), Abraham Shulman(a), Martin L. Lenhardt(b), Douglas G. Richards(b), Alan G. Madsen(b), and Robert Guinta(b)
(a)Martha Entenmann Tinnitus Research Center, Health Science Center at Brooklyn, State University of New York, Brooklyn, NY, and (b)Sound Technique Systems, LLC, and Program in Biomedical Engineering, Virginia Commonwealth University, Richmond, VA
Masking of tinnitus by noise can produce residual inhibition, a persistence in the reduction in tinnitus after the noise is removed. Typically, this relief is very short-lived, on the order of minutes. This report highlights long-term inhibition of tinnitus by UltraQuiet therapy, a new technique that employs patterned sound in the 10- to 20-kHz range, presented through bone conduction. Nine subjects participated in a study of the efficacy of this tinnitus suppression technique. Eight reported improvement in tinnitus symptoms; one did not complete the study. The duration of the improvement ranged from days to weeks. This long-term inhibition may involve a truly plastic change in the brain at the central level.
cortical plasticity; masking; residual inhibition; tinnitus; UltraQuiet
Zhi Cai, Douglas G. Richards, Martin L. Lenhardt, and Alan G. Madsen
Program in Biomedical Engineering, Virginia Commonwealth University, Richmond, VA
Some new therapies for tinnitus employ bone-conducted sound in the high audio and ultrasonic frequencies, but there has been little previous research on sound transmission through the head at these frequencies. The vibrational characteristics of two dry skulls, in comparison to a live human head, were measured in the 2- to 52-kHz range. White noise was played and received through piezoelectric transducers and was Fourier-analyzed. Complex resonances and antiresonances were found in both the dry skulls and the live head and varied with small changes in the position of the transducers. There were also pronounced differences between the skulls. In comparison to the skulls, the live head showed greater attenuation and less prominent resonances and antiresonances, reflecting greater damping. The attenuation of the skulls and the head did not increase consistently with frequency but was dominated by resonances at a variety of frequencies. For designing high audio and ultrasonic tinnitus maskers and hearing aids, these results suggest that wide bandwidth must be used to compensate for the unpredictability of the resonances.
audio; bone conduction; hearing aids; skull; tinnitus; ultrasound
Martin L. Lenhardt (a), Douglas G. Richards (a), Alan G. Madsen (a), Barbara A. Goldstein (b), Abraham Shulman (b) and Robert Guinta (b)
(a)Sound Technique Systems, LLC, and Program in Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, and (b)Martha Entenmann Tinnitus Research Center, Health Science Center at Brooklyn, State University of New York, Brooklyn, NY
For assessment of safety, it is necessary to measure the maximum possible force exerted by a bone conduction device coupled to the human head. Calibration of bone conduction hearing aids and vibrators in the audiometric range is based on measurement of acceleration and force using an artificial mastoid. Extending the measurement to the high audio range was accomplished using a live head. To assess safety of the UltraQuiet tinnitus treatment system, as an example, acceleration was measured from 5 to 20 kHz on a live human head as compared with calibrated levels at 6 kHz on an artificial mastoid and the live head. Using head acceleration and anchoring it to established calibration levels is a means of establishing clinical safety. Stimulation in the high audio frequencies at low levels was found to be safe. In contrast, stimulation with ultrasound requires more energy (approximately 75 - 90 dB re 6 kHz), which may increase the risk of damage to the ear.
high-frequency hearing thresholds; tinnitus; UltraQuiet
Martin L. Lenhardt, Au.D., Ph.D. Professor
Departments of Otolaryngology and Emergency Medicine, Virginia Commonwealth University, Richmond, VA
Masking of tinnitus is possible using high audio frequencies and low-frequency ultrasound. The mechanisms involved in reception and perception of both audio frequencies and ultrasound are identical with the exception that ultrasound interacts with an intermediary site, the brain. We proposed brain ultrasonic demodulation as the means of place-mapping ultrasound on the first few millimeters of the basilar membrane. We present modeling and psychoacoustic data in support of this theory.
high-frequency hearing thresholds; masking; neuroplasticity; pitch; tinnitus
International Tinnitus Journal, Vol. 9, No. 2, 2003
Martin L. Lenhardt, Au.D., Ph.D.